The Magic Bullet Supplement for Stomach Issues – Zinc Carnosine

The Magic Bullet Supplement for Stomach Issues - Zinc Carnosine

TLDR:

  • If you have stomach discomfort (ulcers, H. pylori infection, or gastritis and can only afford one supplement, I would recommend zinc carnosine. It is one of the best supplements for stomach issues.
  • Zinc is a trace mineral that can decrease wound healing time, is important for maintaining the integrity of the immune system, and much more.
  • Zinc is used by the body for testosterone production.
  • Carnosine is both an amino acid and antioxidant.
  • Carnosine is believed to protect organs from oxidative stress and advanced glycation end product damage (diabetic neuropathy).
  • Rarely, high doses of zinc carnosine over a long period may cause zinc toxicity and lowered immune system functioning.
  • My top two recommended brands of zinc carnosine are Peptic-Care ZC and Doctor’s Best PepZin GI.

Quite a few people ask me if they could only afford one supplement to help with stomach discomfort (ulcers,1 H. pylori infection,2 or gastritis3) what supplement would I suggest them to use for their troubles? If I had to choose one digestive supplement that could handle those multiple stomach issues and more it would be zinc carnosine. It is one of the best supplements for stomach issues. Zinc carnosine is the chelation of the mineral zinc and the amino acid carnosine.4

Zinc

Zinc is an important trace mineral that can decrease wound healing time5 and is important for maintaining the integrity of the immune system.6 Zinc is used by the immune system to help develop and maintain function of neutrophils, macrophages, killer cells, and B / T cells.7 Zinc is also a crucial component in the production of the antioxidant enzyme CuZnSOD. 8 Copper and zinc combine with the superoxide dismutase enzyme to produce CuZnSOD. CuZnSOD is a chelated enzyme that has both strong anti-oxidant and anti-inflammatory abilities.9 Zinc in studies has also been known to shorten the duration of childhood diarrhea infections. The mechanism of action of shortening diarrhea infections is that the zinc increases immune system functioning and facilitates toxin elimination.10

Finally, zinc is used in the body in the production of testosterone (limits the amount of DHEA in males that becomes estrogen),11 growth hormones, and insulin-like growth factor-1.12 Zinc is very important for males to supplement in their daily lives. If you do not have stomach issues I would recommend taking fifteen mg of Now L-Optizinc daily, to ensure proper testosterone production.

Different Forms of Zinc

Recommended Forms of Zinc

Zinc L-monomethionine

Zinc L-monomethionine is the form of zinc that I recommend the most (yes, even more than zinc glycinate). Zinc L-monomethionine is a highly absorbed form of zinc with multiple benefits. Zinc L-monomethionine is highly absorbed because it is bounded with the l isomer of methionine. Methionine is an essential amino acid, which means your body cannot produce this amino acid, and it must be supplemented through the diet. Methionine has two isomers (an isomer are molecules with the same molecular formula, but different chemical structures) D and L. The D isomer is synthetic and is created during supplement production. The L isomer is natural and is what the body recognizes as methionine. Therefore, the L isomer has a higher absorption. The extra methionine provided by the zinc supplement is used in the body to make cysteine, carnitine, taurine, lecithin, SAM-e, and phosphatidylcholine.

Methionine, when converted into SAM-e eventually degrades into a byproduct known as homocysteine (excess homocysteine has been linked to being a possible factor in developing heart disease). Homocysteine then is immediately inactivated and turned into either the amino acid cysteine or methionine in the body before any damage can be done as long as adequate B12 and glycine are provided. Methionine is beneficial to the body in supplemental form as long as you take a good B vitamin complex or take a supplement that contains the amino acid glycine. I recommend the Optizinc brand of L-methionine supplements.

Zinc Glycinate

Zinc glycinate is a zinc supplement that is chelated with the amino acid glycine. Glycine reduces anxiety in the body and promotes a feeling of well-being. Check your supplement to see if your glycinate chelate in your supplement is made from the TRAACS Albion process of manufacturing chelates (the supplement should have the TRAACS or Albion logo). Choose a glycinate product that uses TRAACS so you can get the best quality glycinate available.

Zinc Monomethionine

Zinc monomethionine is the brother of Zinc L-methionine and also has great absorption. Zinc monomethionine is not absorbed as well in the human body compared to L-methionine because it contains both of the D and L isomers. When using this supplement a B vitamin complex supplement or glycine supplement may be needed as well to help with absorption and monomethionine regulation. I recommend the Optizinc brand of monomethionine supplements.

Zinc Picolinate

Zinc picolinate is a zinc supplement that is chelated with picolinic acid. Picolinic acid is a compound that is an isomer of niacin and is a carbolite of the amino acid tryptophan. Zinc picolinate has superior absorption and picolinate absorption is superior to even gluconate chelates.

ZMK

A great form of zinc that also includes magnesium chelates from all of the Krebs cycle: citrate, fumarate, malate, succinate, and alpha-keto-glutarate. ZMK is great for athletes and is very good for recovery. A ZMK supplement should be taken before bed.

Zinc Gluconate

A form of zinc that is chelated with gluconic acid which occurs from the natural fermentation of glucose. Zinc gluconate has above average absorption in the body. Zinc gluconate is the type of zinc that is found in products like throat lozenges and nasal spray that are used to shorten the duration of the common cold. The zinc gluconate nasal sprays have been linked to permanent loss of the sense of smell in some people and should be avoided.

Zinc Orotate

Like magnesium orotate, zinc orotate is one of the least known forms of supplemental zinc. The extra orotate will help with muscle regeneration and repair. Women should avoid itt if they are or are trying to become pregnant since it may be mutagenic (only found as a possibility in rats in vivo; and rats are biologically different than humans, therefore it might be safe after all.)

Garbage Forms of Zinc

Zinc Citrate

Zinc citrate is zinc chelated with citric acid. Zinc citrate has an average rate of absorption and can increase stomach acid levels. An animal study showed that the citric acid in the zinc citrate supplement can offset some of the absorption problems if the zinc supplement is taken with a meal high in phytic acid. Citrate may interfere with ceruloplasmin production.

Zinc Oxide

Zinc oxide has a poor absorption rate in the human body. Zinc oxides poor absorption properties is why it is used as a sunscreen and a skin protectant. I only recommend the use of zinc oxide skin care products, but limit the products made with nano zinc oxide which can be absorbed and nano zinc oxide safety has not been fully studied yet.

Zinc Aspartate

The average absorption of zinc aspartate is not worth the extra aspartic acid. Too much aspartic acid may be neurotoxic. This recommendation includes ZMA supplements.

Zinc Pyrithione

Zinc pyrithione is mainly used in anti-dandruff shampoos. Its mechanism of action for eliminating yeast is that it disrupts the yeast’s membrane transport by blocking the proton pump that energizes the transport chain. Zinc pyrithione can cause irritation and allergies, and its use should be limited.

Carnosine

Carnosine is both an amino acid and antioxidant. Most carnosine in the diet comes from the ingestion of red meat. Carnosine is believed to protect the organs from oxidative stress and advanced glycation end products (AGE’s). 13 AGE’s are produced during the break-down of glucose, fructose, and galactose by the body for assimilation. Excess AGE’s that are produced in the body have been linked to a wide range of diseases from diabetes,14 cardiovascular disease,15 to Alzheimer’s disease16 as well. Sadly, the amount of carnosine in most zinc carnosine supplements is tiny and is broken down easily by the enzyme carnosinase, so the effects of the supplemental carnosine would be minimal.17

Zinc Carnosine

Zinc binds quickly to stomach tissue if taken on an empty stomach. If you take a zinc supplement on an empty stomach, it causes severe stomach pain and gastritis. It has been theorized that zinc ions are highly soluble in stomach acid and have corrosive, antimicrobial, and immune-stimulating properties that irritate the stomach tissue because of the direct absorption of the zinc ions. If you chelate zinc with carnosine, the chelation slows down the absorption and elimination of zinc from the stomach. Zinc is then able to repair the stomach and intestinal tissue directly without irritating it. Zinc carnosine may be taken on an empty stomach as needed. Zinc carnosine also protects the stomach lining from opportunistic H. pylori infection, and NSAIDs damage that cause ulcers that come from long-term use of the medication.18

Supplemental Recommendations and Toxicity

High doses of zinc carnosine over a long period can cause zinc toxicity and lowered immune system functioning. Symptoms of zinc toxicity include nausea, vomiting, abdominal pain, frequent colds, increased cholesterol levels, and chills.19 If I had to take a maximum dose of zinc carnosine I would take no more than 450 mg of zinc carnosine (100 mg of elemental zinc) a day total for two weeks. Most supplement instructions recommend taking zinc carnosine twice a day for a total of 75 mg of zinc carnosine daily (15 mg of elemental zinc.)

If you supplement with any other type of zinc, I would recommend no more than 60 mg of elemental zinc daily. If you supplement with 60 mg of zinc, I would suggest that as long as you did not suffer from adrenal fatigue that you should supplement with two mg of Pure Encapsulations Copper Glycinate daily. Zinc and copper balance one another in the body and a good supplementation ratio is for every 15 mg of zinc, one mg of copper is needed (15:1 ratio).

Excessive copper buildup and toxicity can make adrenal fatigue symptoms worse, so limit copper intake during zinc supplementation until adrenals have healed. Zinc carnosine is one of my top three favorite digestive health supplements; everyone should keep a bottle in their medicine cabinet so they can take it when needed.

Supplement Recommendations

Recommended zinc carnosine supplement (it is also what I take daily):

Other recommendations:

Recommended form of zinc L-methionine:

Recommended form of zinc glycinate:

Other recommendation:

Recommended form of zinc monomethionine:

Other recommendation:

Recommended form of zinc picolinate:

Recommended form of zinc citrate:

Other recommendations:

Recommended form of zinc gluconate:

Recommended form of zinc orotate:

101 Comments
  1. Hi. I have post cholestecomy bile salt diahhrea. I’ve been taking Questran (successfully) for this
    condition. Questran binds bile and can also absorb other meds/ so I take all other meds away from
    it. I also have gastritis (endoscopy results not my op dinner …. I take all other meds either 1 hour before
    or 4 hours after these two meals / or at lunch – SO I have been taking zinc L carnosine and don’t know when
    to take it. I can take it with lunch, but that’s only once a day. Should I also be taking it at bedtime or 1 hour before
    the questran? I don’t see how it would help if I took it with my breakfast or dinner / because the questran
    might interfere with it… right? Please also send answer to my email. Thanks.
    Thanks. Nancy

  2. My 18 year-old son has just started taking the zinc carnosine for heartburn recommended by his doctor. He is taking two per day most days, sometimes only one, PepzinGI 75 mg. Do you think he can safely take this dosage for many years without toxicity? I don’t think you consider this to be high dosage. Do you recommend checking copper levels at some point or is that only with other zinc supplementation? Would one zinc gluconate 30 mg. during cold and flu season still not be considered high dosage along with the zinc carnosine? Thank you.

  3. I was reading this and I noticed Im having a problem when ever I take zinc even as small as 10 mg I feel fine that day . But the next day I feel so tired and almost dizzy/fatigued. Why does this happen? Any info or help would be greatly appreciated. Years ago I could take a 50 mg zinc tablet and be fine. I’m only 25 years old

  4. Useful information. Lucky me I found your site accidentally,
    and I am stunned why this twist of fate did not took place
    earlier! I bookmarked it.

  5. What do you think of Zinc Sulfate? https://www.amazon.com/dp/B003C5IP02/?tag=rapefo-20

  6. Hi, my 8 year old son has unfortunately started showing symptoms of H Pylorii for the past couple of months- gerd, burning stomach when empty, abdominal pain, bloating and gas. I too have H Pylorii. Could I give him Zinc Carnosine? I was thinking so far of mastic gum, cranberry and cabbage/broccoli juice for all the family. Artemisinin for me also. Should I consider anything else? I don’t want to go down the antibiotic route unless all else fails. It’s so upsetting to see him suffer. Thanks

  7. Hi John,

    I have relatively high levels of homocysteine – 11.5. Can I still take Zinc L-monomethionine?. Some extra methionine sounds good to me as a result of methylation issues. Thanks!

  8. Is it normal for Solaray optiZinc to burn the stomach? But no problem with Swanson ultra zinc carnosine. Taking zinc carnosine for gastritis and optiZinc for anxiety and panic attacks. You wrote “Zinc may irritate the stomach lining if it is not chelated with carnosine.” Should I try taking zinc carnosine and optiZinc together?

    Cheryl

    • Very common. Zinc binds quickly to stomach tissue if taken on an empty stomach. If you take a zinc supplement on an empty stomach, it causes severe stomach pain and gastritis. It has been theorized that zinc ions are highly soluble in stomach acid and have corrosive, antimicrobial, and immune-stimulating properties that irritate the stomach tissue because of the direct absorption of the zinc ions. If you chelate zinc with carnosine, the chelation slows down the absorption and elimination of zinc from the stomach. Zinc is then able to repair the stomach and intestinal tissue directly without irritating it. Zinc carnosine may be taken on an empty stomach as needed. Zinc carnosine also protects the stomach lining from opportunistic H. pylori infection, and NSAIDs damage that cause ulcers that come from long-term use of the medication. 18

  9. Hi John,

    I have been battling chronic gastritis as of late, and I’ve been taking zinc carnosine to heal it up, while following a high ph diet. This routine seems to help with stomach pain quite a bit if I strictly follow the diet and avoid acidic foods.

    I’ve also been supplementing with pico-ionic magnesium which has helped me feel much better after coming off a long course of cipro for bacterial prostatitis. I would now like to add a zinc supplement to further remedy prostate related issues. Since the pico-ionic magnesium liquid has worked so well for me due to it’s enhanced absorption, would ionic zinc be more easily absorbed than pill or capsule versions of zinc? My stomach is very sensitive, and I can’t seem to tolerate any kind of oral medications due to gastritis related issues. Please let me know your thoughts, thanks in advance!

  10. Hi John

    I am taking Z L-monomethionine for the past several days and have developed a craving for red meat. I am a vegetarian for the most part (eat seafood occasionally). So not sure if this is normal or not.

    Any suggestions?

  11. “Zinc L-monomethionine is a highly absorbed form of zinc with multiple benefits.”
    Hello
    Is there REAL research/study done by reputable institution?
    Thanks

  12. Hi John,
    I am 44 yr male suffering from Candida/Leaky gut. My Magnesium levels are low. Am also Serum Zinc Deficient.Serum Copper is above normal levels. Have been suffering from Menicus tear of both knees. Hscrp is high.Am a vegetarian.
    Does this indicate copper toxicity? I am taking Magtien. Started of with Zinc Acetate which i guess if giving me flatulence. Which Zinc should i try? with copper or without? What other supplements would you recommend.

  13. How do you rate zinc sulphate? It comes in this formula which I am thinking of giving my son?

    https://www.vitabiotics.com/feroglobin/liquid

  14. Hi John,

    You said “Zinc carnosine is one of my top three favorite digestive health supplements”

    What are the other two?

    Great work, by the way.

  15. Is Zinc methionine the same as zinc monomethionine and if not, is it still a good form of zinc?

  16. Hello Mr Brisson
    Thank you for your excellent article
    I have been diagnosed with adrenal insufficiency
    Have had Ulcdrative colitis for many yrs and now I have permanent colostomy
    Recently I had my HTMA and it showed copper toxicity and low on potassium zinc
    I wanted to stet supplement zinc and wanted your input for my situation
    Would zinc picolonate be the good one and how, with at brand, time a day w meals and dose.
    Thank you and looking forward to your reply!

  17. Hi John,

    I have had declining health for the past 3 years.I have been on a long journey trying to find the root of many of my issues. I have PCOS with high testosterone, MTHFR & high homocysteine levels, possible adrenal issues(depressed cortisol in the am, elevated midday and evening and normal at night( 12 hour saliva cortisol test). I have low ferritin (11) and I am very fatigued and unable to sleep at night. My BMI is 18. I have acne and severe hair loss. I have eliminated all gluten and dairy, which has helped some with the severity of the acne and reduced some tummy issues, but not all. I do not know if I should be concerned about copper? What form of zinc would you recommend for pcos? I had an RBC zinc blood test done and it came back at the top of the range level, but I am not sure this is a valid way to measure zinc levels? thank you for your reply in advance!Blessings!

    • RBC zinc test might not be the most accurate because we do not know the turn over rate of your red blood cells.

      Have you had serum copper or ceruloplasmin tested?

      • Hi John,
        thank you for replying. No, I have not had those tested. I am unsure what the second test you mentioned measures?

        Thank you,
        chelsea

        • Ceruloplasmin is a copper transport protein which is used by the body to make sure that copper is used correctly in your body and gets into the cells or is eliminated by the body. It also helps to transport iron.

  18. Hi John,

    Many thanks for this valuable information. I have had issues with gastritis, but I could control it with food and some times with medication and supplements. Now, I have the recommendation to take the Zinc Carnosine 75mg twice per day, but, also I’m taking PhythoMultivitamins from Metagenics.

    Could I take both supplements at the same time, during the meals? Also, do I have to chew the zinc carnosine tablet (even if it doesn’t chewable) or only swallow it? I found a blog where they recommend to chew it… and I’m confused.

    Thank you so much for your answer.
    Beatriz

    • Yes, you should be able to take both supplements at the same time. You do not have to chew up the tablet, it does not matter if it mixes with saliva or not like DGL.

      • Hi again John,

        I have had some issues with gastritis, I had a gastroendoscopy last month and results are normal. However, I still had a light pain in the stomach (upper center).

        I was recommended to take zinc carnosine twice per day. However, as I’m a very sensitive person, I started (Zinlori 75) only one per day with food; but after some days I noticed increased pain and spasms in the stomach as well as a strong metal taste … is it normal?

        Many thanks for you help!
        Beatriz

        • No, most people do not have these symptoms. My guess is that you are strongly refluxing the zinc giving you the taste. If you can taste the zinc then you are deficient in it. I would discontinue it if it is causing stomach pain though.

          • Thank you so much for your replies, they really help me!

  19. Thank you for this post John! Is copper supplementation necessary for zinc absorption? If yes, then what product would you recommend?

    • No, copper would interfere with zinc absorption and vice versa.

    • No, zinc and copper rarely compete with one another for absorption, but it would require high doses for absorption issues to occur. Long term high dose zinc supplementation can interfere in copper bio availability for some people.

  20. Will the zinc carnosine help with GERD? Zinc at 8 mg and L-Carnosine 29.5 mg for 8 weeks?

  21. What a wealth of information! Where did you get your training? I am ordering what your thoughts are on zinc ascorbates and arginate?

    • Zinc ascorbates are fine, but not enough ascorbic acid in it to really make a difference depending on the dosage. Zinc arginate is also fine, but it depends on the amount of arginine one needs and if the supplement can supply enough, arginine and zinc.

  22. Hopefully you will see this Mr Brisson,

    I am going to take your recommendation on the Now L-Optizinc to help optimize my testosterone production. As a weightlifter at the age of 45, I nee all the help I can get! Just a question though, as a weightlifter/bodybuilder I eat a lot of dairy, will this affect absorption?

    Thank you

  23. I am suffering from chronic gastritis, how long can i take drs best zinc carnosine pepcid. I have burning sensation in my stomach, which is relieved to most extent by zinc carnosine. Please suggest as to how long can i take it.

    • Well it depends on a lot of factors like your cellular copper and zinc balance and the amount you are taking daily.

      I have taken it for at least 4 years daily.

  24. Can’t find the L-Methionine anywhere online but there’s plenty of Monomethionine to go around. I also found the TRAACS Albion website but it seems you have to purchase directly from them. If you’re privy to other info on where i can find these two, please let me know.

    kind regards

    • I have not seen it offered by itself most of the time it is in l-optizinc formulations. Just go with what brand of supplement that uses l-optizinc that you like.

    • …& make sure it is L-optizinc
      (there us also the cheaper optizinc, without the L-)

  25. Hey John!
    Thank you so much for the awesome information! My daughter’s doctor told me to put her on zinc picolinate in liquid form. She said that there have been studies that it helps children that are picky eaters to eat better. I’m having a hard time figuring out what is the best zinc picolinate to get in liquid form. I’d love your opinion! Thank you so much for your time!

    • I was unaware that there was one? A did a quick Google search and found nothing I could recommend.

      • Try a compounding chemist (drug store).
        In Sydney, Australia, it is available as Zinc PICOLINATE 10 mg/5ml liquid 500ml for $43.68 from Kingsway Compounding Chemist.

  26. My partner has Stage 4 metastatic melanoma and conventional western medicine has given up all hope for him but I haven’t. I have started him on B17/Laetrile but it highly recommends for it to be taken with zinc as this is used as it’s transport mechanism into the cells. Research on the most bioavailable zinc has me in a bit of a spin so I thought I would ask for your best recommendation (brand/product) in this instance. I look forward to your response. Kind regards

    • You cannot use Optizinc because increased methionione has been linked to cancer. You also have to throw out zinc glycinate because of the same possibility. Zinc citrate is probably your best bet since citrate may have apoptosis effects. https://www.thorne.com/products/dp/zinc-citrate. Of course run everything by his doctor. Look into ketogenic diets and cancer (determine if the cancer cells use glucose or glutamine first) and Rick Simpson Oil.

  27. Hi there

    Is the celluose in this product sugar based or is it ok to take this if off from a sugar diet?

    thanks

    rob

    • It should be fine in a Candida diet. Cellulose is mostly undigested by the human body and what bacteria do break down of it, is considered fiber not a sugar.

  28. Hi John,

    What is your suggestion about zinc orotate and magnesium supplementation. I take about 1200 mg of mag by-glycinate in the evenings to help with Fluoroquinolone toxicity symptoms. Any ideas?

    Thanks,

    Charles

    • Magnesium helps because it is severely depleted in your mitochondria when you took Cipro, most tendon ruptures occur because of this.

      Work or increasing adrenal output, redox potential, and mitochondrial health.

      Follow Jack Kruse’s basic tenets:

      Ingestion of DHA: http://fixyourgut.com/getting-enough-omega-3s/
      Limiting Blue Light At Night / Proper Sleep Hygiene: http://fixyourgut.com/why-proper-sleep-hygeine-is-important-for-digestive-health/
      Reduction of EMF
      Get more sunlight and increase active vitamin D production: https://www.jackkruse.com/the-sunshine-of-your-life/

      Taking ubiquinol with PQQ (Unfair Advantage) may help as well. Vitamin C intake may help with collagen production, more than likely your redox is low and SOD2 was epigenetically changed therefore explains the excess oxidative stress in your body hence tinnitus.

      Follow a good diet like the Perfect Health Diet, avoid low carb, for now, need the carbs for adrenals.

      Look into increasing thyroid function slowly using iodine (detoxadine) and selenium.

  29. I have a question on people with Crohn’s can they take Zinc Carnosine to repair their gut especially when the person is on Remicade infusion? Do you recommend any other alternative solution?

  30. You stated that zinc orotate should be avoided if trying to become pregnant, but what if you already are? My wife is currently pregnant and I’ve had her take Advanced Research Labs zinc orotate during this flu season.

    • The mutagenic studies were only replicated in rats. I would still advice to maybe switch her to other forms of zinc to be 100% safe.

  31. Hi,
    I was wondering if zinc supplements that contain an array of vegetable sources are okay. For example MegaFood Zinc supplements contain broccoli and also the capsule is made up of brown rice and something else. Is that bad? Thank you in advance.
    Here’s the link
    https://www.amazon.com/gp/aw/d/B00GZ9GVHG/ref=ox_sc_act_image_1?ie=UTF8&psc=1&smid=A2G7B63FOSFZJZ#searchKeyword

  32. First of all, I am sorry for your loss.

    Ran across site by searching the diff types of zinc, which I am now even more confused. I am a mom of an adhd 8 yr son and was looking for a safe zinc supplement for I don’t know, memory, brain, research shows adhders need more. All that I’ve searched never states a zinc type. He now does the calc/mag, Nordic complete fish oil, and vitamins which may have synthetics. Anyone’s input :)??

    Frustrated

    • Thank you for your kind words.

      First off because of his age it is hard to recommend zinc, because of the risk of zinc toxicity in children. Granted at his age he could probably tolerate 10 – 15 mg daily, but I still would ask a doctor. Zinc glycinate would be his best bet.

      It would be best for him to get his zinc from grass fed beef.

      • Thanks for your response. I must say, it’s a good feeling to get feedback.
        I do buy grass-fed ground beef and chick. But we don’t eat it everyday. I purchased a multi-v as well as b complex. He loves all veggies! It’s was the zinc part that stumped me. His Dr. Always says he’s fine–he doesn’t need Vit/min testing – happy to do meds.:(

  33. What the best way to take zinc orotate to gain all zinc benefits.
    Thanks

  34. Can some forms of zinc make you tired when others would not? I have tried picolinate and AOR’s brand which is made up of 15 mg zinc
    (citrate, malate, succinate, fumarate) and 2 mg copper (citrate, malate) and both products appeared to make me feel very tired, regardless of when I took them. Is it worth trying some of the other types? What would be a good start?

    (I am looking to correct zinc and copper deficiency as identifed by spectracell lab tests).

    • It is hard to correct a copper deficiency in some people without overloading the adrenal glands. Maybe try to eat beef liver a few times weekly since the copper in it should be ceruloplasmin bound. If zinc by itself is making you tired you have some sort of bacterial or fungal overgrowth.

  35. I have been suffering from gastritis on and off for years. I started taking Zinc Carnosine on a empty stomach and it gave me bad stomach pains. Does it still work if you take it with food or a hour after a meal? Thanks!

    • Zinc carnosine is not supposed to cause stomach pain on an empty stomach like other forms of zinc but it is still possible. Take it with food.

  36. Following my previous question ( the one is safe during pregnancy) I forgot to mention, I take Doctor’s best PepzinGI. Many thanks

  37. Hi,

    Great article. Do you think is safe to take Zinc carnosine during pregnancy? It works great for me but I got pregnant and I’m not sure if I should better stop. Many thanks, Bianca

  38. Great information thank you.
    I have suffered from gastritis for nine years been on PPI all that time and still in agony. I have just started the zinc carnosine how long does it take to work. Thanks so much. Lisa

    • It can take a few days but most people find relief using it I did greatly. DGL chewable can help as well. Have you been tested for H. pylori?

  39. Great article. Which forms of zinc are the best for ADHD symptoms? I have had good results with Zinc Gluconate 50mg, specifically noticng increased focus, almost as good as or equal to amphetamines. I’m really interested in taking Zinc Carnosine though as I’ve had chronic gastritis from heavy NSAID use s/p an orthopedic injury. Does the Zinc Carnosine help with focus as well? Thank you!

    • Zinc carnosine generally stays in the stomach and therefore I do not believe if it would have the same effects of systemic circulation.

      • Thank you John. Looks like it should be cycled and not taken for more than two weeks anyway, so I think I’m going to try it for two weeks, take a break, then switch back to Zinc Gluconate.

        Great article. Which forms of zinc are the best for ADHD symptoms? I have had good results with Zinc Gluconate 50mg, specifically noticng increased focus, almost as good as or equal to amphetamines. I’m really interested in taking Zinc Carnosine though as I’ve had chronic gastritis from heavy NSAID use s/p an orthopedic injury. Does the Zinc Carnosine help with focus as well? Thank you!

        • Zinc gluconate is fine, Carnosine may help with your gastritis and if it is caused by overgrowth then, it may help with your brain fog.

  40. Is Zinc Carnosine as good as Zinc Picolinate for opposing a high copper problem? I take Source Naturals Gastric Soothe (just Zinc-Carnosine) and have not had any stomach problems whatsoever, so I like that idea. I also like the good effects of Carnosine, but just want to be sure that they don’t cancel out the effects or the absorption of the Zinc itself. Also, would I be better off taking the Zinc Carnosine without food or with? Which would provide the best absorption?

    • I believe that Zinc Carnosine is not as effective in opposing copper because it is used in the stomach for repair mainly. It is best to be taken with food.

  41. Thanks for the post John,

    you mention “A ZMK supplement should be taken before bed”,
    i would like to know the reason/reasons/benefits for this please

    daz

    • The zinc and magnesium in the supplement may help with sleep.

      • thx for the reply John.
        i seem to be the ‘exception to the rule’ when it comes to the various recommended supps before bed. including zinc & magnesium.

        but two new supps have just arrived which i have never used before;
        a krebs Zinc (30mg) & a krebs Magnesium (250mg + 100mg potassium).
        so i will pop one of each before bed & see how i go.

        any suggestion as to timings; ‘mins/hours before bed’…?
        & taken on an empty stomach Or with ‘something’…?

        • I would take them with a little bit of almonds thirty minutes before bed. Zinc may irritate the stomach lining if it is not chelated with carnosine.

  42. Thank you for a very informative article and for the many references and links. Would you say it’s essential to take most forms of zinc with a meal to avoid stomach irritation, nausea etc? I mean apart from the Zinc carnosine.

Leave a Reply