GERD Relief Protocol 2: Reduction of H. pylori / Ulcers

GERD Relief Protocol 2: Reduction of H. pylori / Ulcers

GERD Protocol 2: Reduction of H. pylori

More updated information about H. pylori!

In the above blog series we have explored H. pylori in depth. Where it colonizes, why most tests are not that great in detecting it, and how it can either be beneficial or harmful to your health. Now you have discovered that you are suffering from H. pylori overgrowth. What can be done about it, if anything? I have written a four part supplemental protocol to reduce H. pylori growth in the gastrointestinal system in the hope that you can recover.

The protocol includes:

  1. Supplements to change the environment of the gastrointestinal system to impede H. pylori growth.
  2. Supplements to boost one’s immune system to both recognize and fight the H. pylori.
  3. Supplements to reduce H. pylori colonization by attacking the bacteria using anti-microbial agents.
  4. Supplements to reduce the formation of H. pylori biofilm.

Hopefully one can use the following in-depth protocol do reduce H. pylori concentrations throughout the whole gastrointestinal system. There is always a possibility that antibiotics maybe needed to reduce H. pylori overgrowth, especially if it becomes systemic and infects the vagus nerve or the brain for example.

Supplementation Protocol to Reduce H. pylori Colonization

Certain supplements are more localized to the upper-gut, others affect the intestinal or systemic microbiome.

Supplements that would reduce intestine microbiome diversity and should not be used in a first round protocol unless necessary include:

  • Allicin-C
  • Berberine
  • Lactoferrin
  • Interphase plus
  • NAC
  • Oil of oregano

Supplements that work systemically and may reduce systemic microbiome diversity and should not be used unless necessary include:

  • NAC
  • Oil of oregano

Part 1: Anti-microbial Supplements

Depending on the infection load of H. pylori, multiple agents may be needed to achieve remission.

Supplements to Reduce Overgrowth in the Mouth:

  • Colloidal silver (Mesosilver) – take one tablespoon and swish for a few minutes, spit out silver after swishing and wash your mouth out. 1
  • Oil of oregano (North American Herb and Spice) – swish with a few drops for a minute, spit out oil of oregano and wash your mouth out. 2
  • Oil pulling with either organic extra virgin coconut oil or Californian extra virgin olive oil. Take a tablespoon of either oil and swish in your mouth for fifteen to twenty minutes daily. Spit out oil after swishing. Then brush your teeth and swish your mouth out.

Supplements to Reduce Overgrowth in the Stomach and Duodenum:

  • Colloidal silver (Mesosilver) – follow supplement bottle recommendations.
  • Oil of oregano (North American Herb and Spice) – follow supplement bottle recommendations.
  • Berberine – take two capsules, twice daily. 3
  • Allicin-C – two to eight capsules daily in divided doses with food. 4
  • BismuthKaopectate Vanilla (No dyes, but contains some questionable additives including caramel, flavor, sucrose [possible GMO source,] and xanthan gum,) do not use if you have bleeding ulcers.
  • Manuka honey 5

A Supplement Only to be Used in Severe Cases of Overgrowth:

  • Sodium butyrateWARNING, Butyrate lysis’s H. pylori on contact, therefore, it may cause severe gastritis in some people from massive die off and endotoxin release. Might be best to be used with zinc carnosine to help protect the mucosal lining and only taken with food. 6

Part 2: Supplements That Reduce Biofilm Formation

  • Lactoferrin – one to two grams daily, in divided doses with food. 7
  • Interphase plus – one to two capsules, on an empty stomach, twice daily.
  • NAC – (Should only be used in systemic overgrowth of H. pylori,) 600 mg, twice daily with food. 8

Part 3: Supplements That Boost Immune Function

  • Goat Colostrum 9
  • Olive leaf – one – two capsules, twice daily with food. 10
  • S. bouardii – one – two capsules before bed. Use filtered or bottle water when ingesting. 11 12
  • GutPro probiotics – one – two capsules before bed. Use filtered or bottle water when ingesting. 13
  • GOS prebiotic – one – two scoops, mixed well with water, consume during breakfast. 14 15
  • Immunoglobulin Y – follow supplement instructions. 16 17

Part 4: Supplements That Impede H. pylori Growth

  • Betaine HCL – in some people increasing stomach acid production may cause severe inflammation from increased endotoxin production from H. pylori and increased burrowing of the bacteria into the mucosal barrier. Use with caution in systemic stomach overgrowth, or if you have ulcers / gastritis. Supplementation with zinc carnosine, l-carnitine, and activated charcoal may reduce these issues.
  • Broccoli seed extract – one – two capsules, twice daily with food. 18 19
  • D-limonene – one softgel, twice daily with food. 20
  • EGCG – one – two capsules, twice daily with food. 21 22
  • Mastic gum – two capsules, twice daily with food. 23
  • Zinc carnosine – two capsules, three times daily with food. If you are using another brand 40 – 50 mg of zinc from zinc carnosine total, daily in divided doses.

H. pylori Harm Reduction Medication List:

Here are a list of believed safer medications that can be used to tackle H. pylori overgrowth or issues, ask your doctor about developing a regimen from this list.

  • Amoxicillin
  • Bismuth
  • H2 antagonist (may increase growth in the stomach by reducing stomach acid production, but, decreases histamine and may be needed to help recover from gastritis or ulcers, better than PPI, Pepcid is the best one to use.)
  • Tetracycline
  • Third generation cephalosporin

Other antibiotics that have more issues associated with their use:

  • Flagyl
  • Macrolide antibiotics (Clarithromycin for example) – supplementing with magnesium, ubiquinol, and pqq, may help prevent mitochondrial toxicity issues.
  • Rifabutin

Medications to definitely avoid if possible:

  • Fluoroquinolones – supplementing with magnesium, ubiquinol, and pqq, may help prevent mitochondrial toxicity issues.
  • PPI’s


Peptic ulcers are mostly caused by a H. pylori opportunistic infection. 24 Stomach ulcers can also be caused by NSAID use, infections, chronic gastritis, and cancer. The parts of the digestive system, where a person can get an ulcer, is the duodenum, esophagus, stomach, and the diverticulum. 25

The most common symptoms of an ulcer are abdominal pain (stomach ulcer during eating, duodenal ulcer is usually three hours after a meal,) bloating or a sense of fullness, rush of saliva during pain, nausea, vomiting, vomiting of blood, and melena (tarry, dark stools.) If an ulcer is left untreated a perforation can occur (whole in the stomach,) which becomes a medical emergency and must be surgically treat immediately (because of the chance of massive infection and inflammation from bacteria and gastric juice outside the stomach.) The main symptom of a perforation is an extreme stabbing pain in the abdomen and fever. 26

Most ulcers are diagnosed based off of clinical symptoms. But endoscopies and barium X-rays can also be used to diagnose an ulcer.27

Healing a Ulcer (Supplementation)

Zinc carnosine and L-glutamine have been shown in countless studies to repair the stomach and gut lining.

DGL licorice has been shown to heal and protect the stomach lining in multiple studies.

Zinc carnosine is prescribed in Japan to treat ulcers, and DGL is prescribed in Germany to treat ulcers.

Healing a Ulcer (Herbal)

Marshmellow, DGL extract, slippery elm, aloe vera, help coat and protect the stomach lining.

Chamomile help heal inflammation and stimulate the immune system.

  25. Beers, Mark, The Merck Manual, Merck Research Laboratories, 2006
  26. Beers, Mark, The Merck Manual, Merck Research Laboratories, 2006
  27. Beers, Mark, The Merck Manual, Merck Research Laboratories, 2006
  32. Balch, Phyllis. Prescription for Herbal Healing, Avery Publishing, 2012.
  33. Balch, Phyllis. Prescription for Herbal Healing, Avery Publishing, 2012.
  34. Balch, Phyllis. Prescription for Herbal Healing, Avery Publishing, 2012.
  35. Balch, Phyllis. Prescription for Herbal Healing, Avery Publishing, 2012.
  1. Hi John,
    Thank you for putting up such detailed information, the effort you’ve put in is much appreciated. I’ve just been reading your book which is very informative, but a little confused about the H Pylori reduction protocol. Do you recommend taking 1 supplement from each part (1, 2, 3, and 4) or could you start off only taking one and then add more as needed? I was thinking of taking oil of oregano, berberine, lactoferrin, S. Boulardii, and Mastic gum for two weeks, would that be a sufficient protocol? Also I’ve heard of people needing to take supplements for 1 to 2 months; what is your opinion on that? Cheers

    • You should try to take one from each category and more maybe needed from each category depending on the status of the protocol. It might be supplement wise, but you might need to increase the dosage. Some people have followed different protocols for months before they are able to find the right one.

  2. You suggested taking Mastic gum WITH food but in the linked study it was taken before breakfast suggesting that it might be better to take it on the empty stomach. Do you have more info on this?

    • The only reason I suggest to take it with food is so that it does not irritate the stomach lining, it is a general recommendation in my protocol and book. It is best to take on an empty stomach if possible.

  3. Wow, I am glad I stumbled on your comment that Butyrate can cause gastritis as a die-off symptom. I have had my gastritis controlled for a few months now, but when I started taking Butyrate it returned. I tested negative for H Pylori on both a stool and blood test, but I also hear it is hard to diagnose. Looks like I had H pylori after all. Should I continue with the Butyrate, since it does seem to be doing something? Thanks!

  4. Most/all probiotics indicate to be taken with water. What do you think about this article indicating milk might increase absorption?

    • It would make since for L. casei because it is used to ferment dairy and dairy contains all it needs to survive. Milk to increase probiotic delivery may not work properly in strains that cannot ferment lactose. In addition, many people find that they have issues with digesting dairy, which may cause the body to upregulate the immune system which would reduce probiotic growth and facilitate leaky gut.

  5. What do you say about the side effects of the triple therapy (french or italian)?

    Do the given antibiotics destroy bacteria in the small intestine, too? (in case of someone dealing with h pylori and sibo at the same time; would it be hitting two birds with one stone?)

    • It depends on the antibiotic. Some like Rifixamin are strictly used available in the stomach and small intestine. Most antibiotics are systemic in the fact the effect most of the body except the brain (some cross the BBB.)

  6. Have you read The Missing Microbes by Martin Glaser.? His studies point to the fact that h. Pylori is protective against GERD, even thoughnit seems to be causative for ulcers and stomach cancer.

    • Glaser is correct as long as the H. pylori is at normal flora levels in the stomach. When it becomes opportunistic on the other hand it decreases stomach acid, food is poorly digested, and cause gas build up and stomach pressure which causes GERD.

      • What are normal levels of H. pylori, and how are they measured?

        • It is almost impossible to rid the body of H. pylori completely after one is infected with it. Normal flora levels of H. pylori would be levels that did not cause any digestive issues. There are no ways to test yet for this because all methods of testing are either antibody tests for infection or urea breath tests for an overpopulation of bacteria.

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