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Everyone in the natural health community loves Prescript Assist; I guess I am a lone wolf. From Sisson, 1 to Asprey, 2 to Kresser, 3 everyone believes that Prescript Assist or HSO’s are the best things since sliced gluten free bread.
The sad thing is most of the time I agree with Kresser, but this time I cannot stand firmly behind one of my mentors.
However, why is that?
Well, in theory, Prescript Assist appears to be a perfect HSO supplement. The “probiotics” found in the supplement are heat and shelf stable. Most of these HSO’s either are encapsulated in endospores or produce biofilm so hopefully they will be able to survive your stomach acid and propagate freely in the large intestine for your benefit.
Endospores are dormant, tough encapsulations that protect the bacteria from your immune system, antibiotics, antibacterials, and even probiotics. Bacteria can also lay dormant in endospores until their environment becomes favorable for faster reproduction and survival. Bacterial endospores may also become opportunistic in a host, share in a “probiotic” communal with other true probiotics for a time, or slowly replicate more bacteria. Bacterial endospores can survive without nutrients for a long time and are resistant to UV radiation, desiccation, high temperatures, extreme freezing, and most chemical disinfectants. 4
Kresser goes as far as to say that the HSO’s found in Prescript Assist are: 5
“Finally, Prescript-Assist microflora are recognized Class 1 Etiological Agents, non-toxic, non-pathogenic, from independently maintained lines — this is well documented in both of the Clinical Therapeutics Articles. More than a decade of use as a supplement has revealed no adverse effects and/or side-effects [including reportedly patients with impaired immune systems], as well as the initial demonstrations with repeated consumptions of doses amounting to 500X that recommended for ordinarily daily use with no ill effect.”
Well, I will be damned, Prescript Assist is the safest HSO supplement known to mankind!
Too bad for Prescript Assist and Kresser insurmountable scientific data proves otherwise.
The Issues with Prescript Assist
It is unknown if most of the HSO’s in Prescript Assist are part of normal human flora. Many of the HSO’s also have non-existent human studies and no research done on human safety. More information about the interaction between these HSO’s and their human hosts might be known once the human microbiome project 6 is completed, but for now it is truly unknown if any of these bacteria are natural flora in your gut microbiome.
You might be asking yourself what is the big controversy.
The main issue is that using any bacteria or yeast with unknown pathogenic capabilities in even healthy and especially sick people is just asking for trouble. Without research, we simply do not know what these organisms are capable of doing to the human body. Are they harmless and help with us with our digestion? Alternatively, are they capable of severe, hard to treat opportunistic infections?
HSO’s That Are Not Considered Normal Human Flora or Have Non-Existent Human Interaction Research in Prescript Assist 7
- Azospirillum brasiliense
- Azospirillum lipoferum
- Bacillus brevis
- Bacillus marcerans
- Bacillus pumilus
- Bacillus polymyxa
- Bacteroides lipolyticum
- Bacteroides succinogenes
- Kurthia zopfii
- Myrothecium verrucaria
- Pseudomonas calcis
- Pseudomonas denitrificans
- Pseudomonas glathei
- Streptomyces fradiae
- Streptomyces cellulosae
- Streptomyces griseoflavus
Documented Opportunistic HSO’s in Prescript Assist
Remember when Kresser mentioned that the HSO’s in Prescript Assist were non-pathogenic, and no side effects or illnesses have ever been reported from the HSO’s found within the product. Yeah, well I guess he did not do enough research before he made that statement.
- Acinetobacter calcoaceticus 8 9 10 11
- Bacillus subtilis 12
- Phanerochaete chrysosporium 13
- Bacillus pumilus 14
- Pseudomonas fluorescens 15 16
All of these listed HSO’s are known to cause opportunistic infections in humans. Pseudomonas fluorescens has even been implicated as the cause of Crohn’s disease (I believe that it is a coinfection instead of being the direct cause.)
These bacteria can produce hardy endospores and / or biofilm, which make it harder to eliminate them if they become opportunistic. It is a lot easier to eliminate opportunistic Lactobacillus acidophilus then Pseudomonas fluorescens.
I hope you now understand why I cannot recommend any of my clients supplement Prescript Assist, and I hope you take my research and do some investigating of these HSO strains on your own.
See more from this series:
- http://www.marksdailyapple.com/definitive-guide-to-primal-supplementation/#axzz31t4SchA6 ↩
- http://www.bulletproofexec.com/the-red-meat-scapegoat-the-new-york-times-carnitine-heart-disease-and-science/ ↩
- http://store.chriskresser.com/products/prescript-assist-probiotic ↩
- https://micro.cornell.edu/research/epulopiscium/bacterial-endospores ↩
- https://chriskresserlac-shopify.helpjuice.com/questions/47699-Prescript-Assist-and-*spore-forming-organisms* ↩
- http://commonfund.nih.gov/hmp/index ↩
- http://www.prescript-assist.com/ ↩
- http://www.ncbi.nlm.nih.gov/pubmed/846390 ↩
- http://www.ncbi.nlm.nih.gov/pubmed/362918 ↩
- http://link.springer.com/article/10.1007%2FBF01643394#page-1 ↩
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC172888/ ↩
- http://fixyourgut.com/hso-probiotics-part-2-danger-supplementing-bacillus-subtilis/ ↩
- http://onlinelibrary.wiley.com/doi/10.1002/rcr2.31/abstract ↩
- https://goo.gl/sO6jRc ↩
- http://www.gutpathogens.com/content/2/1/16 ↩
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC133002/ ↩