Atrantil for SIBO-C, A Review

Atrantil for SIBO-C, A Review

Atrantil is a new supplement that may help people suffering from SIBO-C or methane dominant SIBO.

I have done a lot of research into this supplement to see if it can live up to its promise to help; you overcome SIBO-C.

My research uncovered some pros and cons associated with the supplement.

I had to dig deep into its possible patent to figure out Atrantil’s proposed mechanism of action. I also reached out to Dr. Brown so that he would provide his explanation of why Atrantil works. I will post the information that I found and some of my interview with him to help you determine if this supplement is right for you. 1

What I found was promising in theory, but there were not a lot of human in vivo studies of two of the main ingredients:

  • Red quebracho tannins
  • Saponins possibly obtained from horse chestnut

Red Quebracho Tannins

Red quebracho is a tree that is found in South America and is an easy source of tannins. Tannins are water-soluble polyphenols that are found in plants and can be quite bitter. Common sources of tannins in our diet are berries, beer, chocolate, nuts, smoked meat, tea, and wine.

Tannins are used in Atrantil to bind, shrink proteins that bacteria produce, and reduce the populations of both protozoa that may be in the gut and methanogenic archaea. It is possible for different bacteria / archaea to be resistant to the antimicrobial effect of tannins, it is unknown rather or not if it will work with your type of overgrowth. Tannins in theory, in a few in vitro studies, and ruminant in vivo studies can inhibit archaea greatly and seem promising in helping people with SIBO-C. 2 3 4 5 6 7

In the interview with Dr. Brown; he mentioned the mechanism of action for the tannins was:

The tannins “Form covalent hydroxyl bonds that bind to free hydrogen.”

He later goes on to state that:

“The Archaebacteria (a methanogen) require hydrogen for methane synthesis.  By binding to the free hydrogen, the Polyphenol removes much of the fuel source for methanogenesis.”

Finally, he mentions the antibacterial properties of the tannins:

“The polyphenol binds to and weakens the cell wall of the archaebacteria, disrupting the integrity of the “S” layers of the cell wall.”

Breaking off those layers weakens the archaea to the next ingredient in the supplement.

Horse Chestnut

Saponins (that I believe are from horse chestnut) are the next ingredient in Atrantil.

Horse Chestnut is a type of tree that is found throughout the world in temperate climates. Its use is mainly known for increasing vascular health from a compound found in the seed of the tree known as aescin. A Saponin is a class of plant compounds that are known to have soap-like foaming actions. Saponins are known to have anti-microbial properties. 8

Dr. Brown mentioned in the interview about the anti-archaea properties of saponins in Atrantil:

“The polycyclic peptide’s amino acids target receptors on the cell wall of the bacteria; form pores by preventing cell wall synthesis resulting in lysing of the bacterial cell.”

He also mentions that the saponins can reduce methane production by the archaea itself:

“Second, the saponin, penetrates the compromised cell wall of the archaebacterial (by the flavonoid). Once inside of the archaebacteria, the saponin binds to methyl-coenzyme M reductase halting methane production within the archaebacteria itself.  This prevents the metabolism of the known methanogen and halts methanogenesis.”

There are studies to back Dr. Brown’s claims in ruminant animals and in vitro studies. 9 10 11 12

Peppermint Oil

Peppermint oil in the supplement is an antispasmodic agent for the intestines. I wrote about menthol extensively in Fix Your Gut and on my blog.

I believe peppermint oil is a double-edged sword for SIBO-C. Dr. Brown believes that it would slow down motility in the small intestine so that the saponins and tannins can do their job efficiently. It does, however, concern me that slowing motility can cause further digestive issues in some people with SIBO-C. Generally, with SIBO-C you want motility to increase, not decrease. If Atrantil works the way that it is proposed to, the brief interruption to the MMC should eventually be overcome by reducing archaea overgrowth. Proper serotonin production in the intestines by reestablishing proper flora should occur, relieving constipation and restoring motility.

Atrantil Final Verdict

I like Atrantil. Will it work for everyone with SIBO-C? Maybe not. But I do recommend it to some of my clients that I feel would get the most benefit from its use who have SIBO-C. I have seen it improve their symptoms in most recommended cases.

I do appreciate the openness of Dr. Kenneth Brown in our e-mail communications and his interview. He does believe in his product and believes that it will improve people’s lives who have SIBO-C.

That being said I do have some small reservations that I mentioned in the above review. I wish there were more human clinical trials with Atrantil and archaea overgrowth or SIBO-C. Dr. Brown has published one small study with great results. I also have some caution with the use of peppermint oil in people with severely reduced MMC function.

Even with my minor criticisms, I recommend that people consider Atrantil if they are suffering from SIBO-C.

  1. Have you had any clients have any side effects with Atrantil? I also wanted to share that my doctor recommended it and gave me a $5 off promo code: MYGUT008 to use on Amazon or

  2. I think I might be a strange case. I have a seriously-distended stomach (think 6-7 months pregnant). Aside from my appearance and the ways my clothes fit, I have NO constipation, NO diarrhea , no stomach distress at all. I have had this for about 2 years, but had to back-burner the issue, due to a cancer diagnosis. I eat primarily plant-based, lots of legumes, cruciferous veggies, leafy vegetables, etc…A recent visit to the GI doc revealed his diagnosis of SIBO. Everything I have read about dietary implications of treating SIBO pretty much flies in the face of what I eat for the cancer. I am very reluctant to go “meat, dairy, beans/sulforaphane -free” etc…

    Which brings me to why I was exploring Atrantil….Is it conceivable that it could just reduce the bloating, since it seems designed to target SIBO-C? Is it reasonable to assume that I wouldn’t have to alter my diet as drastically if I took the Atrantil?

    Any insight you can lend would be greatly appreciated! I have been researching for answers for 3 days nonstop! Thank you in advance.


    this shit has made my life a total misery and cost me nearly 200.00 extra bucks in going to have 2 colonics !
    If you have IBS-C go take some Immodium- it’s basically acts the same way for ppl with monitory problems !

    This is the WORST product I have ever tried and the doc that formulated it and his staff don’t give a hoot- and as said it’s all PRESCIPTED!
    Most Def. A scam website and product
    Buy at ur own risk with ibs -c

    BAD BAD PRODUCT- if you want to have a good BM in a week – by all means take it !

    Good luck – Vince

    • Interesting, I am sorry you had a bad response to it. I have not coached anyone with that much of a reaction. Most people either do well or it does not make that much of a difference. Any supplement or medicine can definitely go wrong.

  4. Hello

    To def acknowledge that the peppermint oil to be problematic as far as motility, it definitely impedes it! Helped the gas and bloating to a degree , however I’m still getting urges to poop and usually I cld get that IBS relief from a BM nothe so with Atranti.
    Rt now I feel constipated and can’t have a BM currently – i did have 3 during the night – it cld be just that tenemus- just miserable condition.
    It’s been ruining my entire life and I suffer from a rare bleeding disorder, that’s a walk in the park compared to this Sibo / IBS -C issue

  5. I’m considering using gutpro with atrantil. Would this be wise? Just eradicated h.pylori about a month ago with the triple therapy treatment.

  6. Hi John,

    Should Atrantil be used INSTEAD of your suggested regime for SIBO-C (as explained here:) or in ADDITION TO it? Or some mix of the two? I’ve just ordered a bottle of the Atrantil and some HCl + Pepsin tabs. I already have Digestive Bitters (Better Bitters Semisweet from Herb Pharm). Should I add in the InterFase and another anti-microbial?

    My symptoms typically present as constipation, bloading, burping, and rumbling sounds after I eat (I’m assuming gas) — if that makes a difference.

    Thanks for your insight!

    • In addition to it for a lot of people. Maybe Interfase or diluted NOW cinammon bark oil would help.

    • A mix of the two, the newest addition of my book has it added to the SIBO-C protocol. Interphase plus may help to reduce biofilm that the hydrogen bacteria produce if you have overgrowth of it feeding the archaea.

  7. Hi, greetings from Peru, first of all congratulations for your excelent blog, you really help us. I have methane SIBO, and my sister who lives in US is sending me Atrantil, its coming in the next days. Im usually taking domperidone , do you think that i can use Domperidone while im taking Atrantil? Thats because domperidone moves your gut. Thanks already for the answer.

  8. This “trial” is going well! I have tried a myriad of remedies for two years to get my digestion in order. In 10 days (2 pills three times a day) I have noticed monumental changes, including an increased motility that I haven’t had in probably 5 years. At least for me this product borders on miracle cure!

  9. Thanks for this.

  10. Are samples of this medication provided? I was diagnosed with IBS in 1984 and have been on several medications for it, I am currently on Donnatel. I am very interested in this medication.

  11. Hi John. Thank you for the review.

    My 2nd SIBO test (as of last week) returned a mild-moderate case of both elevated hydrogen and methane levels. About half of the time (when I eat things like cheese) the bowels are more C, but the other half (when I eat higher fodmap i.e. squashes, nuts), they are not D, but softer, loose.

    My question is this: If I have both elevated Methane and Hydrogen levels, and both mild C and D, is Atrantil a wise choice to include in a 2nd herbal antibiotic regimine (along with allimax, neem, berberine, cinnamon, which my FM doctor has me on?). Your perspective would be appreciated.
    Thank you.

  12. So this could theoretically help with gerd too then right?? =)

    • If your Gerd is caused by archaea overgrowth and slow motility, possibly. The peppermint oil may relax the LES too much and exasperate symptoms.

      • Ok John thanks. Yes I think I will be giving this a shot at some point. Still taking bifido max and galactomune now. Its funny how I went from having ibs most of my life to having GERD instead and I hardly have cramping anymore from everything ive learned through the process

        • John, about your GERD, I read a study where they found that Bifidobacterium animalis caused severe duodinitis in Interleukin-10-deficient mice.

          There are several substrains of B. animalis so it’s not outside the realm of possibility that one of them is in the probiotic you are taking and causing your issue. Just something to possible investigate.

          “Bifidobacterium animalis, or B. animalis, is known by a few different names, which can make it confusing when shopping for a probiotic formula containing it.

          Part of the confusion is because another Bifidus bacteria called bifidobacterium lactis (B. lactis) was merged with B. animalis when their DNA were sequenced and found to have an overwhelming number of similarities.”

  13. what is the diff between sibo c and d? I have the methane type. thankyou!

  14. Have you had any clients use it for SIBO-D?

    • No, and it is not recommended for SIBO-D yet. SIBO-D is a different entity compared to SIBO-C so absorbing methane and limiting archaea, would not help much.

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