Supplements to Combat Biofilm: Part 3

Supplements to Combat Biofilm: Part 3

Supplements that I have recommended in the prior biofilm blog entries were about breaking down and eliminating biofilm.

Are there supplements that can keep biofilm from being able to adhere so that it can be eliminated or not be able to be formed correctly in the first place?

Yes, these supplements do exist, and can help use fight bacterial infections. These supplements are limited in their use though because they have to come directly in contact with the bacterium or be used for an infection to help.


Mannose is sugar and can be used to reduce certain bacterial biofilm formation and adherence in the urinary tract. Mannose is a naturally occurring sugar found in cranberries. 1

D-mannose is effective in reducing E. coli populations in the urinary tract and can help with reducing urinary tract infections. E. coli opportunistic infection is the most common cause of a UTI. It can also disrupt biofilm formation of E. coli and adherence to the urinary tract wall that can help relieve the UTI. 2 3 4

If you believe, you have a UTI, get a bacterial culture done first before you use d-mannose, and if E. coli is the cause, take it.

D-mannose should be safe to use for diabetics, very little of it is metabolized.


Xylitol can reduce bacterial adherence and reduce biofilm formation. Xylitol decreases the polysaccharides that bacteria produce to form biofilms and for cellular adhesion. 5 6

Xylitol works well when it encounters bacteria or the area in which the bacteria grows. I recommend the use of xylitol in wound biofilms, nasal applications, and oral care. Xylitol is able to disrupt the Streptococcus genus very well; it can be used to prevent dental caries (Streptococcus mutans) and MRSA (wounds.) 7 8 9 10

There are bacteria in the gut flora that can ferment xylitol and cause issues in people with overgrowth. In addition, xylitol is poorly absorbed by the colon and can cause an osmotive laxative effect in high doses. I do not recommend the use of xylitol and other sugar alcohols to reduce biofilm in people with SIBO. 11

Both of these supplements have limited use in combating biofilm, but can be a great help when needed.

  1. What are your thoughts on the effectiveness and safety of lumbrokinase as a biofilm disruptor?

    • It might be ok as long as you are not using any blood thinning medications. There is one study of people taking it with heart issues for at least a month and it appeared to be safe. As always make sure you ask your healthcare professional first before using it. It can help break down fibrin which would break down some biofilms. Staph uses fibrin to produce biofilms.

  2. D Mannose feeds candida. I get tired of running into recommendations to take it, for people with gut problems, without any mention of this potential issue with this supplement.

    • No studies on D mannose and Candida. Anecdotal evidence is mixed, some people saw improvement some people did not. It is a sugar, therefore I would not use it to tackle UTI’s that are caused by yeast.

  3. You write as if all biofilms are bad. That’s not necessarily true. Biofilms can be very beneficial…

    • I never said that all biofilm producing bacteria were bad. Bifidobacterium for example can produce beneficial biofilms.

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