Jason Hooper and John Brisson discuss HSO’S!
Show notes provided by ACH85. Thank you!
Hangout with Hooper 7/15/2015 Show Notes
- 1:00 – set your YouTube account to public if you want to be eligible to win a free Unfair Advantage prize.
- 3:00 – Talking about Homeostatic Soil Organisms (HSO’s) and John and Jason seem to have a very controversial stance, since people have attacked (and hacked) Jason and John because they have said they have questions about HSO’s.
- 5:00 – S. Boulardii is an exception and seems to be an OK HSO. MegaSpore started getting emails questioning the product because of John’s article, talked to John and Jason to provide some new info about HSO’s… but no change in opinion yet.
- 9:00 – While they’re “soil based organisms,” probiotics source them from labs, not soil, so HSO is sort of a misnomer now. It would be more accurate to call them “endospore producing bacteria,” but no one would know what that is. Lactobacillus and Bifidobacteria do not produce endospores.
- 12:00 – Jason took probiotics after surgery and got a fever, worked with John, and found that he had Bacillus subtilis in his small intestine (where it’s not supposed to be) via a small intestinal biopsy. Used John’s protocol with a biofilm chelator and EDTA (but be careful with EDTA!)
- 16:00 – A lot of companies mislabel Bacillus cereus which causes food poisoning, and claim it to be Bacillus subtilis. It’s easy to get food poisoning from Bacillus cereus in cooled but not refrigerated white rice.
- 19:00 – Major supplement companies are putting out probiotics with no idea which bacterial strains are actually in them. Fix Your Gut is planning to buy some probiotics, culture them, and see what’s actually in them.
- 20:00 – Common unrefrigerated, non-enterric-coated probiotics are likely to be dead when they’re eaten, but you could get a noticeable immune reaction, and also see them show up (still dead) in a stool sample.
- 23:00 – It’s often the toxins from the bacteria that make you sick with food poisoning, not the bacteria itself.
- 25:00 – Bacillus spores seem to have survived the trip to Mars on a rover. Bacillus spores are all over the place, and we all ingest them to some degree.
- 27:00 – Bacillus has been treated with antibiotics, but will it just revert to spore form and “hide?” We don’t know. Very few human in vivo safety studies.
- 28:00 – Bacteria have developed many means to survive through time, sometimes including antibiotics to kill competing bacteria.
- 29:00 – Any bacteria can cause problems with small intestinal overgrowth, no matter how benign. It’s possible for spore-forming bacteria to eliminate problematic bacteria, but if your gut motility isn’t active enough, then the spore former can take over in place of the old bacteria.
- 32:00 – Horizontal gene transfer: bacteria can swap genes amongst each other. This is probably why antibiotic resistance is becoming a problem. But we don’t know how likely horizontal gene transfer is, since species that have survived for a long time are likely to have stable genetics. Horizontal gene transfer seems more likely between similar genera of bacteria.
- 39:00 – With supplements including probiotics, most companies don’t post their testing, and many supplements may not contain the dosages or even the ingredients they claim. The FDA has a “generally recognized as safe” (GRAS) list, but it doesn’t have a great track record (like trans fats.) You can ask for a a COA to be sure what you’re getting, though some companies won’t provide it. Don’t buy from them.
- 44:00 – Good supplements with good testing are EXPENSIVE to make.
- 52:00 – Jason takes a high-level view, less about species and more about which genes are in the total gut microbiome of an individual. What genes do we not have that we want? What’s the safest thing we can take to get those genes?
- 53:00 – Would suppository work?
- 56:00 – If you see a probiotic with 10-15 different cultures, chances are they’re dead. John says the probiotic industry today is in a state of crisis, a wild west.
- 57:00 – The future may be “printing” your own bacteria.
- 59:00 – Dr. Grace Liu has a “core list” of bacteria she thinks we’re supposed to have that you can check out.
- 60:00 – Please comment if you disagree but don’t hack anyone.